It is actually difficult to identify what constitutes a standard harmful or lethal dose. Nonetheless, the lethal oral dose of codeine in an adult is reported to get during the selection of 0.
NMS is a significant condition that can lead to death. End getting promethazine/codeine and contact your Health care provider without delay if you have any of the next signs or symptoms.
Rinse out the measuring machine after you take a dose of promethazine/codeine to be certain any residual drugs is washed out.
The mixture of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric patients fewer than 6 decades of age, because the combination may trigger deadly respiratory melancholy With this age inhabitants.
Despite the fact that antihistamines are actually located to make fetal mortality in rodents, the pharmacological consequences of histamine from the rodent never parallel People in guy. There are no ample and effectively-managed scientific studies of promethazine in Expecting women.
Promethazine HCl and Codeine Phosphate Oral Resolution needs to be applied with caution in people with impairment of hepatic functionality, and sufferers should be monitored closely for respiratory depression, sedation, and hypotension.
Just take promethazine/codeine accurately as prescribed. Tell your healthcare company if check here you think that promethazine/codeine is not Doing work. Get in touch with your Health care company at get more info once or head to the nearest emergency room When you have any of the subsequent severe indicators.
The causal role of opioids from the medical syndrome of hypogonadism is unidentified because the numerous medical, physical, Way of living, and psychological stressors that may affect read more gonadal hormone levels have not been sufficiently controlled for in experiments done thus far [see Adverse Reactions (six)].
Keep at area temperature away from light and dampness. Never store in the bathroom. Don't freeze liquid kinds of this medication. Maintain all drugs from small children and pets.
Material use dysfunction or Stay with someone that misuses alcohol, Avenue medications, or prescription medicines
Acute or intense bronchial bronchial asthma in an unmonitored location or in absence of resuscitative gear. (4)
Everyday living-threatening respiratory problems (respiratory depression). Promethazine Hydrochloride and Codeine Phosphate Oral Resolution can result in respiratory challenges (respiratory depression) that could take place at any time all through therapy and can result in Demise. Your possibility of respiratory challenges is finest once you first start out taking Promethazine Hydrochloride and Codeine Phosphate Oral Resolution, are using other medicines that might cause respiration problems, have specific lung get more info complications, are elderly or have particular other medical problems.
The diagnostic analysis of patients with this syndrome is intricate. In arriving in a analysis, it can be crucial to identify situations where by the clinical presentation consists of both significant clinical disease (e.
The diagnostic evaluation of sufferers with this syndrome is intricate. In arriving more info in a diagnosis, it is vital to determine situations the place the medical presentation consists of both equally serious health-related ailment (e.